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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 6
1997 13
1998 24
1999 24
2000 30
2001 47
2002 40
2003 47
2004 46
2005 30
2006 41
2007 49
2008 45
2009 34
2010 49
2011 31
2012 22
2013 15
2014 13
2015 10
2016 15
2017 11
2018 9
2019 10
2020 10
2021 12
2022 8
2023 9
2024 2

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638 results

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Page 1
Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies.
Chong SJF, Zhu F, Dashevsky O, Mizuno R, Lai JX, Hackett L, Ryan CE, Collins MC, Iorgulescu JB, Guièze R, Penailillo J, Carrasco R, Hwang YC, Muñoz DP, Bouhaddou M, Lim YC, Wu CJ, Allan JN, Furman RR, Goh BC, Pervaiz S, Coppé JP, Mitsiades CS, Davids MS. Chong SJF, et al. J Clin Invest. 2023 Nov 15;133(22):e170169. doi: 10.1172/JCI170169. J Clin Invest. 2023. PMID: 37751299 Free PMC article.
Additionally, we provide evidence that antiapoptotic BCL-2 family protein phosphorylation altered the apoptotic protein interactome, thereby changing the profile of functional dependence on these prosurvival proteins. Targeting BCL-2 family protein phosphoryl …
Additionally, we provide evidence that antiapoptotic BCL-2 family protein phosphorylation altered the apoptotic protein intera …
Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Saygin C, Giordano G, Shimamoto K, Eisfelder B, Thomas-Toth A, Venkataraman G, Ananthanarayanan V, Vincent TL, DuVall A, Patel AA, Chen Y, Tan F, Anthony SP, Chen Y, Shen Y, Odenike O, Teachey DT, Kee BL, LaBelle J, Stock W. Saygin C, et al. Clin Cancer Res. 2023 Aug 15;29(16):3151-3161. doi: 10.1158/1078-0432.CCR-23-0415. Clin Cancer Res. 2023. PMID: 37363966 Free PMC article.
BCL-2/BCL-xL dual inhibitors were effective against both subtypes of T-lineage ALL. A 71-protein human phosphokinase array showed increased LCK activity in ven-R cells, and increased ACK1 activity in ven-R and NWP-R cells. ...ACK1 signaling upregulated AKT pathway, which i …
BCL-2/BCL-xL dual inhibitors were effective against both subtypes of T-lineage ALL. A 71-protein human phosphokinase array showed inc …
Bad is essential for Bcl-xL-enhanced Bax shuttling between mitochondria and cytosol.
Mai Z, Sun H, Yang F, Du M, Cheng X, Chen H, Sun B, Wen J, Wang X, Chen T. Mai Z, et al. Int J Biochem Cell Biol. 2023 Feb;155:106359. doi: 10.1016/j.biocel.2022.106359. Epub 2022 Dec 29. Int J Biochem Cell Biol. 2023. PMID: 36586532
It is still unclear what causes the difference in Bcl-xL-regulated Bax localization. Bad, a BH3-only protein with a high affinity for Bcl-xL, may play an important role in Bcl-xL-regulated Bax shuttling. ...In addition, MK-2206, an Akt inhibitor, decreased Bad …
It is still unclear what causes the difference in Bcl-xL-regulated Bax localization. Bad, a BH3-only protein with a high affin …
BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival.
Tan Y, Demeter MR, Ruan H, Comb MJ. Tan Y, et al. J Biol Chem. 2000 Aug 18;275(33):25865-9. doi: 10.1074/jbc.M004199200. J Biol Chem. 2000. PMID: 10837486 Free article.
Protein kinase A, RSK1, and survival factor signaling stimulate phosphorylation of BAD at Ser-155, blocking the binding of BAD to Bcl-XL. RSK1 phosphorylates BAD at both Ser-112 and Ser-155 and rescues BAD-mediated cell death in a manner depende …
Protein kinase A, RSK1, and survival factor signaling stimulate phosphorylation of BAD at Ser-155, blocking the binding of …
Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia.
Abe T, Takagi N, Nakano M, Furuya M, Takeo S. Abe T, et al. Brain Res. 2004 May 29;1009(1-2):159-68. doi: 10.1016/j.brainres.2004.03.003. Brain Res. 2004. PMID: 15120593
We investigated the effects of transient (15 min) global ischemia on the intracellular localization of Bad and the interaction of Bad with calcineurin, Akt or Bcl-xL in the vulnerable CA1 and resistant CA3/dentate gyrus of the hippocampus. ...Further, we examined th …
We investigated the effects of transient (15 min) global ischemia on the intracellular localization of Bad and the interaction of …
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells.
Hafeez S, Urooj M, Saleem S, Gillani Z, Shaheen S, Qazi MH, Naseer MI, Iqbal Z, Ansari SA, Haque A, Asif M, Mir MA, Ali A, Pushparaj PN, Jamal MS, Rasool M. Hafeez S, et al. PLoS One. 2016 Jan 8;11(1):e0145780. doi: 10.1371/journal.pone.0145780. eCollection 2016. PLoS One. 2016. PMID: 26745145 Free PMC article.
Evidence for inhibition of ERK1/2 by deguelin and escape of BAD phosphorylation at serine 112 through ERK/RSK pathway has been further fortified by obtaining similar results by silencing ERK 1/2 each with specific siRNAs. Increase in BAD after treatment with degueli …
Evidence for inhibition of ERK1/2 by deguelin and escape of BAD phosphorylation at serine 112 through ERK/RSK pathway has been furthe …
ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD.
Shen J, Wu Y, Xu JY, Zhang J, Sinclair SH, Yanoff M, Xu G, Li W, Xu GT. Shen J, et al. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):35-46. doi: 10.1167/iovs.09-3544. Epub 2009 Jul 23. Invest Ophthalmol Vis Sci. 2010. PMID: 19628748
Real-time RT-PCR and Western blot analysis were used to detect Bcl-xL, Bcl-2, Bax, BAD, and products of extracellular signal regulated kinase (ERK) and Akt pathways. ...Glyoxal upregulated Bax expression but suppressed Bcl-xL expression and BAD phosphorylation. In c …
Real-time RT-PCR and Western blot analysis were used to detect Bcl-xL, Bcl-2, Bax, BAD, and products of extracellular signal regulate …
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
Macdonald A, Campbell DG, Toth R, McLauchlan H, Hastie CJ, Arthur JS. Macdonald A, et al. BMC Cell Biol. 2006 Jan 10;7:1. doi: 10.1186/1471-2121-7-1. BMC Cell Biol. 2006. PMID: 16403219 Free PMC article.
Mutation of Ser136 to alanine prevented the phosphorylation of Ser112 and Ser155 by Pim kinases in HEK-293 cells, suggesting that this site must be phosphorylated first in order to make the other sites accessible. Pim phosphorylation of Bad was also found to promote the 14 …
Mutation of Ser136 to alanine prevented the phosphorylation of Ser112 and Ser155 by Pim kinases in HEK-293 cells, suggesting that this site …
Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis.
Yang J, Li JH, Wang J, Zhang CY. Yang J, et al. J Theor Biol. 2010 Sep 21;266(2):231-41. doi: 10.1016/j.jtbi.2010.06.009. Epub 2010 Jun 9. J Theor Biol. 2010. PMID: 20540951
Our research results reveal that BAD is phosphorylated and inactivated on Ser 75 in a BAD-Bcl-xL complex by PKA (targeted to mitochondria through association with WAVE1), resulting in the dissociation of BAD and its binding to GK. ...The BAD complex mo …
Our research results reveal that BAD is phosphorylated and inactivated on Ser 75 in a BAD-Bcl-xL complex by PKA (targeted to m …
Evaluating the inhibitory priority of Bcl-xL to Bad, tBid and Bax by using live-cell imaging assay.
Wu G, Tu Z, Yang F, Mai Z, Chen H, Tang Q, Ye X, Wang K, Wang X, Chen T. Wu G, et al. Cytometry A. 2021 Nov;99(11):1091-1101. doi: 10.1002/cyto.a.24351. Epub 2021 Apr 22. Cytometry A. 2021. PMID: 33843148 Free article.
Fluorescence images of living cells co-expressing CFP-Bcl-xL and YFP-Bad or YFP-tBid or YFP-Bax showed that Bcl-xL markedly inhibited Bad/tBid/Bax-mediated apoptosis, revealing that Bcl-xL inhibits the proapoptotic function of Bad, tBid and Bax. In the case o …
Fluorescence images of living cells co-expressing CFP-Bcl-xL and YFP-Bad or YFP-tBid or YFP-Bax showed that Bcl-xL markedly inhibited …
638 results